Awet Muda Dimulai Dari Usus: Mengungkap Kaitan Leaky Gut dengan Penuaan dan Cara Mengatasinya
Keywords:
kanker pankreas, diagnosis, biomarkerSynopsis
Buku ini disusun sebagai kontribusi ilmiah dalam memahami keterkaitan antara integritas usus, mikrobiota, dan proses penuaan biologis. Dalam beberapa dekade terakhir, perhatian ilmiah terhadap peran usus dalam menjaga homeostasis sistemik dan memperlambat penuaan meningkat secara signifikan. Buku ini hadir sebagai hasil kajian multidisipliner yang menggabungkan bidang gastroenterologi, imunologi, nutrisi, dan neurobiologi dalam sebuah kerangka pemahaman holistik. Konsep leaky gut atau sindrom usus bocor tidak lagi dianggap sebagai isu periferal, melainkan telah diakui sebagai salah satu faktor pemicu inflamasi kronis tingkat rendah yang berdampak pada metabolisme, sistem saraf, hingga fungsi imun. Melalui pendekatan berbasis bukti, buku ini menguraikan berbagai faktor yang menyebabkan kerusakan penghalang usus, implikasi sistemiknya terhadap proses degeneratif, serta strategi pemulihan melalui intervensi diet, probiotik, manajemen stres, dan aktivitas fisik. Setiap bab dirancang untuk membimbing pembaca memahami dinamika usus sebagai organ sentral dalam kesehatan jangka panjang. Disertai dengan studi kasus dan testimoni, buku ini diharapkan mampu menjembatani pengetahuan teoretis dan praktik aplikatif, baik bagi kalangan akademik, profesional kesehatan, maupun masyarakat umum yang peduli terhadap penuaan sehat. Penulis berharap semoga kehadiran buku ini dapat memberikan perspektif baru dan solusi berbasis ilmiah dalam upaya menjaga vitalitas dan memperpanjang usia fungsional manusia melalui pendekatan kesehatan usus.
References
Alfas, F. (2018). Systemic inflammation, leaky gut and brain fog: A new model linking chronic inflammation to neuropsychiatric symptoms. Journal of Neuroinflammation, 1(5), 78.
Biagi, E., Franceschi, C., Rampelli, S., Severgnini, M., Ostan, R., Turroni, S., et al. (2016). Gut microbiota and extreme longevity. Current Biology, 26(11), 1480–1485. [https://doi.org/10.1016/j.cub.2016.04.016]
Castro-Mejía, J.L., Khakimov, B., Krych, Ł., Bülow, J., Bechshøft, R.L., Højfeldt, G., et al. (2020). Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures. Aging Cell, 19(3), e13105. [https://doi.org/10.1111/acel.13105]
Collino, S., Montoliu, I., Martin, F.P.J., Scherer, M., Mari, D., Salvioli, S., et al. (2013). Metabolic signatures of extreme longevity in Northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLoS ONE, 8(3), e56564. [https://doi.org/10.1371/journal.pone.0056564]
Costa, R.J.S., Snipe, R.M.J., Kitic, C.M. Gibson, P.R. (2017). Systematic review: Exercise-induced gastrointestinal syndrome—Implications for health and intestinal disease. Alimentary Pharmacology & Therapeutics, 46(3), 246–265. [https://doi.org/10.1111/apt.14157]
DeMeo, M.T., Mutlu, E.A., Keshavarzian, A., Tobin, M.C. (2002). Intestinal permeability defects in irritable bowel syndrome: A pilot study. Neurogastroenterology and Motility, 14(6), 669–675. [https://doi.org/10.1046/j.1365-2982.2002.00342.x]
Del Bo’, C., Bernardi, S., Marino, M., Porrini, M., Tucci, M., Guglielmetti, S. Cherubini, A. (2021). Polyphenol-rich diet and gut microbiota modulation in older adults: The MaPLE study. Clinical Nutrition, 40(8), 4455–4466. [https://doi.org/10.1016/j.clnu.2021.01.014]
Donati Zeppa, S., Agostini, D., Piccoli, G., Stocchi, V., Sestili, P., Gervasi, M. (2023). Interventions on gut microbiota for healthy aging. Cells, 12(1), 34. [https://doi.org/10.3390/cells12010034]
Fasano, A. (2012). Leaky gut and autoimmune diseases. Clinical Reviews in Allergy and Immunology, 42(1), 71–78. [https://doi.org/10.1007/s12016-011-8291-x]
Kavanagh, K., Wylie, A.T., Tucker, K.L., Hamp, T.J., Gharaibeh, R.Z., Fodor, A.A., et al. (2019). Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations. GeroScience, 41(6), 923–933. [https://doi.org/10.1007/s11357-019-00112-z]
Peron, G., Sut, S., Pellizzaro, A., Brun, P., Voinovich, D., Castagliuolo, I. and Dall’Acqua, S. (2021). Crosstalk among intestinal barrier, gut microbiota and serum metabolome after a polyphenol-rich diet in older subjects with “leaky gut”: The MaPLE trial. Clinical Nutrition, 40, 5288–5297. [https://doi.org/10.1016/j.clnu.2021.08.027]
Peterson, C.T., Sharma, V., Elmen, L. and Peterson, S.N. (2015). The gut microbiome and inflammation in chronic disease: A functional perspective. Clinical Therapeutics, 37(5), 796–805. [https://doi.org/10.1016/j.clinthera.2015.03.021]
Poto, R., Troisi, J., Sarnataro, D., Di Minno, A., Capaldo, B. and Castaldo, G. (2024). The role of gut microbiota and leaky gut in the pathogenesis of food allergy. Nutrients, 16(1), 92. [https://doi.org/10.3390/nu16010092]
Quaranta, G., Sanguinetti, M., Masucci, L., Fiori, B. (2022). Fecal microbiota transplantation and gut microbiota manipulation for the treatment of aging-associated disorders. Microorganisms, 10(12), 2424. [https://doi.org/10.3390/microorganisms10122424]
Rose, E.C., Odle, J., Blikslager, A.T., Ziegler, A.L. (2021). Probiotic and prebiotic regulation of tight junction proteins in the gut epithelium. International Journal of Molecular Sciences, 22(13), 6729. [https://doi.org/10.3390/ijms22136729]
Salazar, J., Enrich, C., Valdés-Varela, L., Gueimonde, M. (2023). Exploring the relationship between gut microbiota and aging: Possible age modulators. International Journal of Environmental Research and Public Health, 20(7), 5845. [https://doi.org/10.3390/ijerph20075845]
Sato, Y., Atarashi, K., Plichta, D.R., Arai, Y., Sasajima, S., Kearney, S.M., et al. (2021). Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. Nature, 599(7885), 458–464. [https://doi.org/10.1038/s41586-021-03832-5]
Serek, P., Oleksy-Wawrzyniak, M. (2021). Impact of bacterial infections, probiotics, and zonulin on gut barrier integrity. International Journal of Molecular Sciences, 22(21), 11359. [https://doi.org/10.3390/ijms222111359]
Sharma, R. (2022). Emerging links between gut microbiome and cellular senescence in aging and disease: Perspectives and therapeutic opportunities. Probiotics and Antimicrobial Proteins, 14(3), 648–663. [https://doi.org/10.1007/s12602-021-09903-3]
Singh, S., Giron, L. B., Shaikh, M. W., Shankaran, S., Engen, P. A., et al. (2024). Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging. Microbiome, 12(1), 31. [https://doi.org/10.1186/s40168-024-01758-4]
Sonowal, R., Swimm, A., Sahoo, A., Luo, L., Matsunaga, Y., Wu, Z., et al. (2017). Indoles from commensal bacteria extend healthspan. Proceedings of the National Academy of Sciences, 114(36), E7506–E7515. [https://doi.org/10.1073/pnas.1706464114]
Untersmayr, E., Knittelfelder, O., Riemer, A.B. and Jensen-Jarolim, E. (2022). Gut barrier dysfunction and inflammaging. Nutrients, 14, 949. [https://doi.org/10.3390/nu14050949]
Van Wijck, K., Lenaerts, K., Van Bijnen, A.A., Boonen, B., Van Loon, L.J.C., Dejong, C.H.C., et al. (2012). Physiology and pathophysiology of splanchnic hypoperfusion and intestinal injury during exercise: Strategies for evaluation and prevention. American Journal of Physiology-Gastrointestinal and Liver Physiology, 303(2), G155–G168. [https://doi.org/10.1152/ajpgi.00066.2012]
Veres-Székely, A., Sárközi, A., Korcsmáros, T. and Hritz, I. (2023). Zonulin as a potential therapeutic target in aging and inflammation-related disorders. International Journal of Molecular Sciences, 24(7), 7548. [https://doi.org/10.3390/ijms24087548]
Vijay, A., Valdes, A.M. (2022). Role of the gut microbiome in chronic diseases: A narrative review. European Journal of Clinical Nutrition, 76(4), 489–501. [https://doi.org/10.1038/s41430-021-00991-6]
Wilmanski, T., Diener, C., Rappaport, N., Patwardhan, S., Wiedrick, J., Lapidus, J., et al. (2021). Gut microbiome pattern reflects healthy ageing and predicts survival in humans. Nature Metabolism, 3(2), 274–286. [https://doi.org/10.1038/s42255-021-00348-0]
Yan, H., Ren, J. and Liu, G.H. (2023). Fecal microbiota transplantation rejuvenates the aged gut microbiota to restore gut and brain functions. hLife, 1(1), 8–11. [https://doi.org/10.1016/j.hlife.2023.06.002]
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